Dr. Henry Goose / Hotel Manager / Isaac Sachs / Dermot Hoggins / Cavendish Look-a-Like Actor / Zachry
Tom Hanks
Native Woman / Jocasta Ayrs / Luisa Rey / Indian Party Guest / Ovid / Meronym
Halle Berry
Captain Molyneux / Vyvyan Ayrs / Timothy Cavendish / Korean Musician / Prescient 2
Jim Broadbent
Haskell Moore / Tadeusz Kesselring / Bill Smoke / Nurse Noakes / Boardman Mephi / Old Georgie
Hugo Weaving
Adam Ewing / Poor Hotel Guest / Megan's Dad / Highlander / Hae-Joo Chang / Adam / Zachry Brother-in-Law
Jim Sturgess
Tilda / Megan's Mom / Mexican Woman / Sonmi-451 / Sonmi-351 / Sonmi Prostitute
Bae Doona
Cabin Boy / Robert Frobisher / Store Clerk / Georgette / Tribesman
Ben Whishaw
Kupaka / Joe Napier / An-kor Apis / Prescient
Keith David
Young Rufus Sixsmith / Old Rufus Sixsmith / Nurse James / Archivist
James D'Arcy
Talbot / Hotel Manager / Yoona-939 / Rose
Zhou Xun
Autua / Lester Rey / Duophsyte
David Gyasi
Madame Horrox / Older Ursula / Yusouf Suleiman / Abbess
Susan Sarandon
Rev. Giles Horrox / Hotel Heavy / Lloyd Hooks / Denholme Cavendish / Seer Rhee / Kona Chief
Hugh Grant
Old Salty Dog / Mr. Meeks / Prescient 1
Robert Fyfe
Mr. Boerhaave / Guard / Leary the Healer
Martin Wuttke
Megan Sixsmith / 12th Star Clone
Zhu Zhu
Young Cavendish
Robin Morrissey
Javier Gomez / Jonas / Zachry's Older Nephew
Brody Nicholas Lee
